Alzheimer’s disease clinical trial begins at UH medical school

A clinical trial on a drug that researchers hope will reduce inflammation in patients with Alzheimer’s Disease will begin at the University of Hawaiʻi at Manoa John A. Burns School of Medicine (JABSOM).
The JABSOM trial involves an investigational therapy, NP001, developed by Neuraltus Pharmaceuticals, Inc., a privately held biopharmaceutical company dedicated to developing innovative therapeutics for neurodegenerative diseases.

Courtesy: University of Hawaiʻi at Manoa John A. Burns School of Medicine

This study aims to determine whether a single dose of NP001 will affect blood markers that indicate inflammation in individuals with mild-to-moderate Alzheimer’s disease.

Alzheimer’s disease, an irreversible, progressive brain disorder that slowly destroys memory and thinking skills, is currently ranked as the sixth leading cause of death in the United States. While the cause of the disease is unknown, there is increasing evidence that suggests neuroinflammation may play a role in disease progression.

Courtesy: University of Hawaiʻi at Manoa John A. Burns School of Medicine

NP001, Neuraltus Pharmaceuticals’ lead investigative therapy, is designed to help regulate neuroinflammation.

“Although Alzheimer’s disease is the most common cause of dementia, there is presently no cure for the more than five million Americans living with the disease,” said Beau Nakamoto, an associate professor in the Department of Medicine and principal investigator. “Given the key role inflammatory monocytes and macrophages may play in the progression of Alzheimer’s disease, researching immune regulators—like NP001—is critical to understanding more about this serious and complex disease.”

Applications are still being accepted. To sign up call:

Debbie – (808) 692-1332
Lorna – (808) 692-1333

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Diane Ako

Peace of mind By Diane Ako I like to reflect on life. Sometimes it’s philosophically. Sometimes it’s humorously. For all its beauty, life is far too difficult a journey to take alone. You need the support and connection with others to help carry you along the way. Writing brings me that connection– within and without. It clarifies my thoughts and feelings. It helps me reach out to others for advice, wisdom, or feedback. Your thoughts become your actions. Your actions become you. A wise yogi- Patanjali- said, “Speak what is true. Speak what is pleasant.” Let’s speak of things pleasant to one another and seek some peace of mind along the way. ABOUT Diane Ako joined Hawaii: In Real Life in October 2016. She likes being part of a community of local bloggers – people who like writing and sharing, like she does. Ako is an anchor/ reporter at Island News (KITV4 – ABC) in Honolulu. She previously anchored and reported at KHON2 (FOX) and KHNL (NBC), and at stations in California, New Mexico, and Pennsylvania. She freelance writes for NMG Network's magazines. In between news jobs, in 2017, she launched and ran her own p.r. company, Diane Ako PR. From 2010-2014, she headed the public relations department at Halekulani Corporation, which oversees luxury resort Halekulani and boutique hotel Waikiki Parc. She’s been blogging since 2009 – before Hawaii: IRL, she wrote for The Honolulu Star-Advertiser, the state’s largest daily newspaper, where her stories garnered a dozen journalism awards and an Emmy nomination. Ako has a BA in Communications from Menlo College and an MA in Political Science from University of Hawaii at Manoa. She volunteers as a board member of the Honolulu Gay & Lesbian Cultural Foundation, a Shinto shrine maiden at Daijingyu Temple, a citizen-scientist studying shrimp, and a yoga teacher at a senior center.

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